Identification of the First Retinoid X Receptor Homodimer Antagonist

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Bibliographic Details
Published inJournal of medicinal chemistry Vol. 39; no. 17; pp. 3229 - 3234
Main Authors Canan Koch, Stacie S, Dardashti, Laura J, Hebert, Jonathan J, White, Steven K, Croston, Glenn E, Flatten, Karen S, Heyman, Richard A, Nadzan, Alex M
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 16.08.1996
Amer Chemical Soc
Subjects
Animals
Antineoplastic agents
Biological and medical sciences
Cell Line
Cercopithecus aethiops
Chemistry, Medicinal
DNA-Binding Proteins - antagonists & inhibitors
General aspects
HL-60 Cells
Humans
Indicators and Reagents
Kinetics
Life Sciences & Biomedicine
Medical sciences
Molecular Structure
Pharmacology & Pharmacy
Pharmacology. Drug treatments
Receptors, Retinoic Acid - antagonists & inhibitors
Receptors, Retinoic Acid - biosynthesis
Recombinant Proteins - antagonists & inhibitors
Recombinant Proteins - biosynthesis
Retinoid X Receptors
Retinoids - chemical synthesis
Retinoids - chemistry
Retinoids - pharmacology
Science & Technology
Structure-Activity Relationship
Transcription Factors - antagonists & inhibitors
Transcription Factors - biosynthesis
Transcriptional Activation
Transfection
ACID RECEPTOR
DNA-BINDING
SELECTIVE RETINOIDS
THYROID-HORMONE
DIRECT REPEATS
PROLIFERATOR-ACTIVATED RECEPTOR
BINDING-PROPERTIES
RESPONSE PATHWAYS
HETEROCYCLIC RING
NUCLEAR RECEPTOR
Antineoplastic agent
Ether
Structure activity relation
Naphthalene(1,2,3,4-tetrahydro)
Affinity
Aromatic compound
Antagonist
Retinoids
Mechanism of action
Chemical synthesis
Biological receptor
Cis stereoisomer
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Bibliography:ark:/67375/TPS-3P8VHBRJ-G
istex:45A4DE22EBF8ADBC0F8C77010C8276A8D5442369
ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0022-2623
1520-4804
DOI:10.1021/jm960311d