Gadolinium Complexes Functionalized Persistent Luminescent Nanoparticles as a Multimodal Probe for Near-Infrared Luminescence and Magnetic Resonance Imaging in Vivo
The development of multimodal nanoprobes that combined properties of near-infrared (NIR) fluorescence and magnetic resonance imaging (MRI) within a single probe is very important for medical diagnosis. The NIR-emitting persistent luminescent nanoparticles (PLNPs) are ideal for optical imaging owing...
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Published in | Analytical chemistry (Washington) Vol. 86; no. 9; pp. 4096 - 4101 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Chemical Society
06.05.2014
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Subjects | |
Online Access | Get full text |
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Summary: | The development of multimodal nanoprobes that combined properties of near-infrared (NIR) fluorescence and magnetic resonance imaging (MRI) within a single probe is very important for medical diagnosis. The NIR-emitting persistent luminescent nanoparticles (PLNPs) are ideal for optical imaging owing to no need for in situ excitation, the absence of background noise, and deep tissue penetration. However, no PLNP based multimodal nanoprobes have been reported so far. Here, we report a novel multimodal nanoprobe based on the gadolinium complexes functionalized PLNPs (Gd(III)-PLNPs) for in vivo MRI and NIR luminescence imaging. The Gd(III)-PLNPs not only exhibit a relatively higher longitudinal relaxivity over the commercial Gd(III)-diethylenetriamine pentaacetic acid complexes but also keep the superlong persistent luminescence. The prepared Gd(III)-PLNPs multimodal nanoprobe offers great potential for MRI/optical imaging in vivo. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0003-2700 1520-6882 |
DOI: | 10.1021/ac500644x |