1,3,4-Thiadiazole: Synthesis, Reactions, and Applications in Medicinal, Agricultural, and Materials Chemistry

• Published in: Chemical reviews Vol. 114; no. 10; pp. 5572 - 5610
• Main Authors: Hu, Yang, Li, Cui-Yun, Wang, Xiao-Ming, Yang, Yong-Hua, Zhu, Hai-Liang
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 28.05.2014
• Subjects: Agricultural chemicals; Animals; Anti-Infective Agents - chemical synthesis; Anti-Infective Agents - chemistry; Anti-Infective Agents - pharmacology; Antiparasitic Agents - chemical synthesis; Antiparasitic Agents - chemistry; Antiparasitic Agents - toxicity; Bacteria - drug effects; Biotechnology; Chemical engineering; Chemical properties; Chemical reactions; Chemical synthesis; Electrochemical Techniques; Euglenozoa - drug effects; Fungi - drug effects; Hydrazides; Hydrazines - chemistry; Oxadiazoles - chemistry; Solid phases; Synthesis; Thiadiazoles - chemical synthesis; Thiadiazoles - chemistry; Thiadiazoles - pharmacology

The synthesis, reactions and medicinal applications of the 1,3,4-thiadiazole ring in solution and the solid phase were investigated. The physical and chemical properties of biosostere and the reactions of aromatic and heterocyclic hydrazides with triethyl orthoformate were also explored.