Efficient Routes to a Diverse Array of Amino Alcohol-Derived Chiral Fragments
Efficient syntheses of chiral fragments derived from chiral amino alcohols are described. Several unique scaffolds were readily accessed in 1–5 synthetic steps leading to 45 chiral fragments, including oxazolidinones, morpholinones, lactams, and sultams. These fragments have molecular weights rangin...
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Published in | ACS combinatorial science Vol. 18; no. 9; pp. 569 - 574 |
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Main Authors | , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
12.09.2016
Amer Chemical Soc |
Subjects | |
Online Access | Get full text |
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Summary: | Efficient syntheses of chiral fragments derived from chiral amino alcohols are described. Several unique scaffolds were readily accessed in 1–5 synthetic steps leading to 45 chiral fragments, including oxazolidinones, morpholinones, lactams, and sultams. These fragments have molecular weights ranging from 100 to 255 Da and are soluble in water (0.085 to >15 mM). |
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Bibliography: | NIH RePORTER ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2156-8952 2156-8944 2156-8944 |
DOI: | 10.1021/acscombsci.6b00050 |