CuAAC: An Efficient Click Chemistry Reaction on Solid Phase

• Published in: ACS combinatorial science Vol. 18; no. 1; pp. 1 - 14
• Main Authors: Castro, Vida, Rodríguez, Hortensia, Albericio, Fernando
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 11.01.2016
• Subjects: Alkynes; Alkynes - chemical synthesis; Alkynes - chemistry; Azides - chemical synthesis; Azides - chemistry; Catalysis; Click Chemistry - economics; Click Chemistry - methods; Combinatorial analysis; Copper - chemistry; Cycloaddition Reaction - economics; Cycloaddition Reaction - methods; Meetings; Molecular structure; Nucleotides; Nucleotides - chemical synthesis; Nucleotides - chemistry; Peptides - chemical synthesis; Peptides - chemistry; Polymers; Polymers - chemical synthesis; Polymers - chemistry; Small Molecule Libraries - chemical synthesis; Small Molecule Libraries - chemistry; Solid phases; Solid-Phase Synthesis Techniques - economics; Solid-Phase Synthesis Techniques - methods; Synthesis (chemistry); alkyne; solid-phase; Click Chemistry; azide; CuAAC
• ISSN: 2156-8952; 2156-8944; 2156-8944
• DOI: 10.1021/acscombsci.5b00087

Click chemistry is an approach that uses efficient and reliable reactions, such as Cu­(I)-catalyzed azide–alkyne cycloaddition (CuAAC), to bind two molecular building blocks. CuAAC has broad applications in medicinal chemistry and other fields of chemistry. This review describes the general features and applications of CuAAC in solid-phase synthesis (CuAAC-SP), highlighting the suitability of this kind of reaction for peptides, nucleotides, small molecules, supramolecular structures, and polymers, among others. This versatile reaction is expected to become pivotal for meeting future challenges in solid-phase chemistry.