Polymersomes for Therapeutic Delivery of Protein and Nucleic Acid Macromolecules: From Design to Therapeutic Applications

Macromolecule-based therapeutic agents, particularly proteins, antigens, monoclonal antibodies, transcription factors, nucleic acids, and gene editing enzymes, have the potential to offer cures for previously untreatable diseases. However, they present an enormous delivery challenge due to poor abso...

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Published inBiomacromolecules Vol. 21; no. 4; pp. 1327 - 1350
Main Authors Iqbal, Shoaib, Blenner, Mark, Alexander-Bryant, Angela, Larsen, Jessica
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 13.04.2020
Subjects
absorption
antigens
enzymes
gene editing
gene transfer
immune response
metabolism
monoclonal antibodies
nucleic acids
therapeutics
transcription factors
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Summary:Macromolecule-based therapeutic agents, particularly proteins, antigens, monoclonal antibodies, transcription factors, nucleic acids, and gene editing enzymes, have the potential to offer cures for previously untreatable diseases. However, they present an enormous delivery challenge due to poor absorption and rapid metabolism in the body. Polymersomes have tremendous potential in delivering these agents to their desired intracellular location due to increased circulation times, decreased macromolecule degradation, and decreased immune responses. In this Review, we highlight the key factors in design, development, and improved performance of these vesicles for macromolecular delivery. The recent progress made toward preclinical application of these vesicles for protein and gene delivery is also covered.
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ISSN:1525-7797
1526-4602
1526-4602
DOI:10.1021/acs.biomac.9b01754