Properties of a Versatile Nanoparticle Platform Contrast Agent To Image and Characterize Atherosclerotic Plaques by Magnetic Resonance Imaging

The need for more specific and selective contrast agents for magnetic resonance imaging motivated us to prepare a new nanoparticle agent based on high-density lipoproteins (HDL). This second generation contrast agent can be prepared in three different ways. The HDL nanoparticles (rHDL) were fully ch...

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Bibliographic Details
Published inNano letters Vol. 6; no. 10; pp. 2220 - 2224
Main Authors Frias, Juan C, Ma, Yanqing, Williams, Kevin Jon, Fayad, Zahi A, Fisher, Edward A
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 01.10.2006
Subjects
Analytical, structural and metabolic biochemistry
Animals
Atherosclerosis - pathology
Biological and medical sciences
Contrast Media
Cross-disciplinary physics: materials science; rheology
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
Image Enhancement - methods
Lipoproteins, HDL - chemistry
Magnetic Resonance Imaging - methods
Materials science
Mice
Miscellaneous
Nanopowders
Nanoscale materials and structures: fabrication and characterization
Nanostructures - chemistry
Physics
Proteins
High density
Gel electrophoresis
Macromolecules
Magnetic resonance
Confocal microscopy
Experimental study
Flexibility
Gel permeation chromatography
Nanoparticles
Image analysis
Lipoproteins
Imaging
Nanostructured materials
Fluorescence microscopy
Organic compounds
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Summary:The need for more specific and selective contrast agents for magnetic resonance imaging motivated us to prepare a new nanoparticle agent based on high-density lipoproteins (HDL). This second generation contrast agent can be prepared in three different ways. The HDL nanoparticles (rHDL) were fully characterized by FPLC and gel electrophoresis. The flexibility of the platform also allows us to incorporate optical probes into rHDL for localization ex vivo by confocal fluorescence microscopy. The contrast-agent-containing nanoparticles were injected into mice that develop atherosclerotic lesions. Magnetic resonance imaging of the animals showed clear enhancement of the atherosclerotic plaques.
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ISSN:1530-6984
1530-6992
DOI:10.1021/nl061498r