Bioactive Terpenoids from Octocorallia. 3. A New Eunicellin-Based Diterpenoid from the Soft Coral Cladiella sphaeroides

• Published in: Journal of natural products (Washington, D.C.) Vol. 60; no. 4; pp. 393 - 396
• Main Authors: Yamada, Koji, Ogata, Narumi, Ryu, Kenjiro, Miyamoto, Tomofumi, Komori, Tetsuya, Higuchi, Ryuichi
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.04.1997; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Analytical, structural and metabolic biochemistry; Biological and medical sciences; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; Chemistry, Medicinal; Cladiella sphaeroides; cladiellaperoxide; cladiellisin; COMPOSICION QUIMICA; COMPOSITION CHIMIQUE; CORAIL; CORALES; CORALS; CREVETTE; DITERPENOIDE; DITERPENOIDS; DITERPENOS; ESPECTROMETRIA; ESTRUCTURA QUIMICA; Fundamental and applied biological sciences. Psychology; GAMBAS Y CAMARONES; JAPAN; JAPON; LETHAL DOSE; Life Sciences & Biomedicine; Marine; Octocorallia; Other biological molecules; Pharmacology & Pharmacy; Plant Sciences; PRAWNS AND SHRIMPS; Science & Technology; SPECTRAL ANALYSIS; SPECTROMETRIE; SPECTROMETRY; STRUCTURE CHIMIQUE; Terpenes, steroids. Hormones; TOXICIDAD; TOXICITE; TOXICITY; Asia; Japan; INW, Japan, Kyushu, Miyazaki Prefect; Artemia salina; Toxicity; Animal origin; Tricyclic compound; Oxygen heterocycle; Crustacea; Marine environment; Coelenterata; Arthropoda; Cnidaria; Absolute configuration; Bicyclic compound; Diterpene; Isolation; Invertebrata; Branchiopoda; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np9605605

A new diterpenoid, cladiellaperoxide (2), has been isolated from the soft coral Cladiella sphaeroides, together with the known diterpenoid cladiellisin (1). Their structures were characterized by NMR studies and chemical conversion. The absolute configurations of 1 and 2 have been elucidated by the modified Mosher method. Compound 2 showed lethality toward brine shrimp.