Antineoplastic Agents, 177. Isolation and Structure of Phyllanthostatin 6

The isolation and structural elucidation of a new Phyllanthus glycoside, phyllanthostatin 6 [7], was summarized. Phyllanthostatin 6 [7] was isolated from the roots of Phyllanthus acuminatus (Euphorbiaceae) and was found to inhibit (ED50 = 0.35 micrograms/ml) growth of the murine P-388 lymphocytic le...

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Bibliographic Details
Published inJournal of natural products (Washington, D.C.) Vol. 53; no. 6; pp. 1406 - 1413
Main Authors Pettit, George R, Schaufel-berger, Daniel E, Nieman, Ronald A, Dufresne, Claude, Saenz-Renauld, J. A
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.11.1990
Subjects
Animals
ANTIEOPLASTIC AGENTS
Antineoplastic Agents, Phytogenic - chemistry
Antineoplastic Agents, Phytogenic - isolation & purification
Benzofurans - chemistry
Benzofurans - isolation & purification
Benzofurans - pharmacology
CELL CULTURE
CELL LINES
Chromatography, High Pressure Liquid
CULTIVO DE CELULAS
CULTURE DE CELLULE
CYTOTOXIC COMPOUNDS
CYTOTOXICITY
GLICOSIDOS
GLYCOSIDE
GLYCOSIDES
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
LEUCEMIA
LEUCEMIE
LEUKAEMIA
LEUKEMIA
Leukemia P388 - drug therapy
Mice
MOLECULAR CONFORMATION
Molecular Structure
PHYLLANTHUS
PHYLLANTHUS ACUMINATUS
Plants - analysis
Pyrans - isolation & purification
RACINE
RAICES
ROOTS
Sesquiterpenes
Spectrum Analysis
Spiro Compounds
SUBSTANCE TOXIQUE
SUSTANCIAS TOXICAS
TOXIC SUBSTANCES
TOXICIDAD
TOXICITE
TOXICITY
Tumor Cells, Cultured
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Summary:The isolation and structural elucidation of a new Phyllanthus glycoside, phyllanthostatin 6 [7], was summarized. Phyllanthostatin 6 [7] was isolated from the roots of Phyllanthus acuminatus (Euphorbiaceae) and was found to inhibit (ED50 = 0.35 micrograms/ml) growth of the murine P-388 lymphocytic leukemia cell line. Two other new constituents were shown to be didesacetylphyllanthostatin 3 [9] and descinnamoylphyllanthocindiol [10]. Structure determinations were achieved employing hrfabms and 2D-nmr spectroscopy. Application of an hplc separation technique to the Phyllanthus glycosides and development of a new isolation procedure for the major antineoplastic constituent, phyllanthoside [1], are also described.
Bibliography:9328908
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ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0163-3864
1520-6025
DOI:10.1021/np50072a002