Antibiotic Trapping by Plasmid-Encoded CMY-2 β-Lactamase Combined with Reduced Outer Membrane Permeability as a Mechanism of Carbapenem Resistance in Escherichia coli

• Published in: Antimicrobial Agents and Chemotherapy Vol. 57; no. 8; pp. 3941 - 3949
• Main Authors: GOESSENS, Wil H. F, VAN DER BIJ, Akke K, VAN BOXTEL, Ria, PITOUT, Johann D. D, VAN ULSEN, Peter, MELLES, Damian C, TOMMASSEN, Jan
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.08.2013
• Subjects: Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Antibiotics; Antibiotics. Antiinfectious agents. Antiparasitic agents; Bacterial Outer Membrane Proteins; Bacterial Outer Membrane Proteins - genetics; Bacterial Outer Membrane Proteins - metabolism; beta-Lactamases; beta-Lactamases - genetics; beta-Lactamases - metabolism; Biological and medical sciences; Cell Membrane Permeability; Cephalosporins - pharmacology; Drug Resistance, Multiple, Bacterial; Enzyme Activation; Escherichia coli; Escherichia coli - drug effects; Escherichia coli - enzymology; Escherichia coli - genetics; Escherichia coli Infections - drug therapy; Escherichia coli Proteins - genetics; Escherichia coli Proteins - metabolism; Female; Humans; Hydrolysis; Mechanisms of Resistance; Medical sciences; Microbial Sensitivity Tests; Periplasm - drug effects; Pharmacology. Drug treatments; Plasmids; Plasmids - genetics; Plasmids - metabolism; Protein Binding; Thienamycins; Thienamycins - pharmacology; Thienamycins - therapeutic use; Young Adult; Enzyme; β-Lactams; Escherichia coli; Permeability; β-Lactamase; External membrane; Plasmid; Resistance; Antibiotic; Carbapenem derivatives; Trapping; Bacteria; Hydrolases; Antibacterial agent; Mechanism of action; Enterobacteriaceae
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.02459-12

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