Dysoxylins A−D, Tetranortriterpenoids with Potent Anti-RSV Activity from Dysoxylum gaudichaudianum

• Published in: Journal of natural products (Washington, D.C.) Vol. 70; no. 2; pp. 312 - 315
• Main Authors: Chen, Jian Lu, Kernan, Michael R, Jolad, Shivanand D, Stoddart, Cheryl A, Bogan, Mark, Cooper, Raymond
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.02.2007; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Antiviral Agents - chemistry; Antiviral Agents - isolation & purification; Antiviral Agents - pharmacology; antiviral properties; Biological and medical sciences; chemical structure; Chemistry, Medicinal; dysoxylin; Dysoxylum; Dysoxylum gaudichaudianum; General pharmacology; human health; Life Sciences & Biomedicine; Medical sciences; Meliaceae; Meliaceae - chemistry; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Papua New Guinea; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Plants, Medicinal - chemistry; Respiratory syncytial virus; Respiratory Syncytial Viruses - drug effects; Science & Technology; tetranortriterpenoid; Triterpenes - chemistry; Triterpenes - isolation & purification; Triterpenes - pharmacology; triterpenoids; Papua New Guinea; SYNCYTIAL VIRUS; RICHII; LIMONOIDS; Human respiratory syncytial virus; Pneumovirinae; Pharmacognosy; Bark; NMR spectrometry; In vitro; Meliaceae; Biological activity; Paramyxoviridae; Medicinal plant; Virus; Mononegavirales; Dicotyledones; Angiospermae; Plant origin; Antiviral; Isolation; Spermatophyta; Inhibition; Pneumovirus; Mass spectrometry; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np060398y

Four new compunds, belonging to the tetranortriterpenoid family, named dysoxylins A−D (1−4), isolated from Dysoxylum gaudichaudianum, were found to exhibit potent antiviral activity against respiratory syncytial virus (RSV). These structures were determined by NMR spectroscopy and mass spectrometry and were shown to have anti-RSV EC50 activities in the range 1.0−4.0 μg/mL in cytopathic effect inhibition and plaque reduction assays.