An HIV RNase H Inhibitory 1,3,4,5-Tetragalloylapiitol from the African Plant Hylodendron gabunensis
A new compound, 1,3,4,5-tetragalloylapiitol (1), was isolated from the aqueous extract of the plant Hylodendron gabunensis and was found to be a potent inhibitor of RNase H enzymatic activity. The structure of 1 was elucidated by NMR analyses to be an apiitol (2) sugar moiety substituted with four g...
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Published in | Journal of natural products (Washington, D.C.) Vol. 70; no. 10; pp. 1647 - 1649 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
WASHINGTON
American Chemical Society
01.10.2007
Amer Chemical Soc American Society of Pharmacognosy |
Subjects | |
Online Access | Get full text |
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Summary: | A new compound, 1,3,4,5-tetragalloylapiitol (1), was isolated from the aqueous extract of the plant Hylodendron gabunensis and was found to be a potent inhibitor of RNase H enzymatic activity. The structure of 1 was elucidated by NMR analyses to be an apiitol (2) sugar moiety substituted with four gallic acid residues. Optical rotation measurements of the free sugar following basic hydrolysis indicated that the 3S absolute configuration was the same as that of d-apiitol. Compound 1 inhibited HIV-1, HIV-2, and human RNase H with IC50 values of 0.24, 0.13, and 1.5 µM, respectively, but it did not show inhibition of E. coli RNase H at 10 µM. |
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Bibliography: | http://dx.doi.org/10.1021/np0702279 istex:45F7F44710F5793507342D9D6E010C62174EBCC4 1H, 13C, and 2D NMR spectra for compound 1. This material is available free of charge via the Internet at http://pubs.acs.org. ark:/67375/TPS-LZ79J6J4-4 Medline ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0163-3864 1520-6025 |
DOI: | 10.1021/np0702279 |