Diterpenoids, Norditerpenoids, and Secosteroids from the Formosan Soft Coral Cespitularia hypotentaculata

• Published in: Journal of natural products (Washington, D.C.) Vol. 69; no. 8; pp. 1188 - 1192
• Main Authors: Duh, Chang-Yih, Li, Chia-Hua, Wang, Shang-Kwei, Dai, Chang-Feng
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.08.2006; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Animals; Anthozoa; Anthozoa - chemistry; anticarcinogenic activity; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Biological and medical sciences; cespitolide; cespitularane diterpene; Cespitularia hypotentaculata; cespitularin; cesputularin; chemical structure; Chemistry, Medicinal; Computer Simulation; corals; cultured cells; cytotoxicity; Diterpenes - chemistry; Diterpenes - isolation & purification; Diterpenes - pharmacology; diterpenoids; Drug Screening Assays, Antitumor; General pharmacology; humans; Leukemia P388; Life Sciences & Biomedicine; Medical sciences; Mice; Molecular Conformation; Molecular Structure; norditerpenoids; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; Science & Technology; secosteroids; Secosteroids - chemistry; Secosteroids - isolation & purification; Secosteroids - pharmacology; spectral analysis; stereochemistry; steroids; Taiwan; Tumor Cells, Cultured; verticillane diterpene; xenicane diterpene; Asia; Taiwan; Steroid; Terpenoid; Pharmacognosy; Animal origin; Cytotoxicity; In vitro; Biological activity; Marine environment; Coelenterata; Cnidaria; Diterpene; Isolation; Cholestane derivatives; Invertebrata; Tumor cell; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np0505465

Four new cespitularane diterpenes, cesputularins I−L (1−4), two new norverticillane norditerpenes, cespitularins M and N (5 and 6), two new verticillane diterpenes, cespitularins O and P (7 and 8), a new norditerpene, cespitularin Q (9) (having a novel carbon skeleton), a new xenicane diterpene, cespitolide (10), and two new secosteroids, 3β,11-dihydroxy-5β,6β-epoxy-9,11-secocholestan-9-one (11) and 3β,11-dihydroxy-5β,6β-epoxy-9,11-secogorgostan-9-one (12), were isolated from the methylene chloride solubles of the Formosan soft coral Cespitularia hypotentaculata Roxas. The structures were elucidated by extensive spectroscopic analysis, and their cytotoxicity against selected cancer cells was measured in vitro.