Effect on the Uptake Kinetics of Serotonin (5-hydroxytryptamine) in Platelets from Workers with long-term Exposure to Organic Solvents a Pilot Study

• Published in: Scandinavian Journal of Work, Environment ＆ Health Vol. 10; no. 4; pp. 229 - 234
• Main Authors: Beving, Håkan, Kristensson, Jan, Malmgren, Rigmor, Olsson, Per, Unge, Gunnar
• Format: Journal Article
• Language: English
• Published: Finland Scandinavian Journal of Work, Environment ＆ Health 01.08.1984; National Board of Occupational Safety and Health; The Working Environment Fund; Swedish Medical Society, Section for Environmental Health; Work Research Institutes; Institute of Occupational Health
• Subjects: Adult; Air Pollutants, Occupational - adverse effects; Blood; Blood plasma; Blood Platelets - metabolism; Breathing; Calcium; Calcium - blood; Environmental Exposure; Humans; Hydrogen-Ion Concentration; Kinetics; Male; Middle Aged; Pilot Projects; Platelet Count; Platelets; Potassium - blood; Referents; Serotonin - blood; Serotonin receptors; Sodium; Sodium - blood; Solvents; Solvents - adverse effects; Time Factors; plasma; serum; metal ions
• ISSN: 0355-3140; 1795-990X
• DOI: 10.5271/sjweh.2337

Six workers from a paint industry were examined concerning the concentration of solvents in the breathing zone, the platelet count and kinetic uptake of serotonin [5-hydroxytryptamine (5-HT)], the serum concentration of calcium, potassium and sodium, and pH. The degree of exposure was found to be moderate. The results showed a decrease in platelet count in whole blood and platelet-rich plasma. The maximum uptake rate for serotonin in platelets (Vmax) was significantly increased compared to that of nonexposed subjects. No changes in the ionic concentration and pH of serum were observed. One worker was reexamined after a six-week period of nonexposure. Though the measured platelet variables were still aberrant, the values approached normal.