Long-Lasting Antifouling Coating from Multi-Armed Polymer

• Published in: Langmuir Vol. 29; no. 32; pp. 10087 - 10094
• Main Authors: Mizrahi, Boaz, Khoo, Xiaojuan, Chiang, Homer H, Sher, Katalina J, Feldman, Rose G, Lee, Jung-Jae, Irusta, Silvia, Kohane, Daniel S
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 13.08.2013
• Subjects: Animals; Biofouling - prevention & control; Catechols - chemistry; Cattle; Cell Survival; Chemistry; Colloidal state and disperse state; Dopamine - chemical synthesis; Dopamine - chemistry; Exact sciences and technology; Fibroblasts - cytology; General and physical chemistry; Membranes; Mice; Molecular Structure; Molecular Weight; NIH 3T3 Cells; Polyethylene Glycols - chemical synthesis; Polyethylene Glycols - chemistry; Serum Albumin, Bovine - chemistry; Surface Properties; Titanium - chemistry; Binding; Fouling; Device; Transition element compounds; Polymer; Adhesion; Protein; Aggregation; Thickness; Particle; Chemistry; Membrane; Titanium oxide; Molecular mass
• ISSN: 0743-7463; 1520-5827
• DOI: 10.1021/la4014575

We describe a new antifouling surface coating, based on aggregation of a short amphiphilic four-armed PEG-dopamine polymer into particles and on surface binding by catechol chemistry. An unbroken and smooth polymeric coating layer with an average thickness of approximately 4 μm was formed on top of titanium oxide surfaces by a single step reaction. Coatings conferred excellent resistance to protein adhesion. Cell attachment was completely prevented for at least eight weeks, although the membranes themselves did not appear to be intrinsically cytotoxic. When linear PEG or four-armed PEG of higher molecular weight were used, the resulting coatings were inferior in thickness and in preventing protein adhesion. This coating method has potential applicability for biomedical devices susceptible to fouling after implantation.