Isolation, Structural Elucidation, MS Profiling, and Evaluation of Triglyceride Accumulation Inhibitory Effects of Benzophenone C‑Glucosides from Leaves of Mangifera indica L

• Published in: Journal of agricultural and food chemistry Vol. 61; no. 8; pp. 1884 - 1895
• Main Authors: Zhang, Yi, Han, Lifeng, Ge, Dandan, Liu, Xuefeng, Liu, Erwei, Wu, Chunhua, Gao, Xiumei, Wang, Tao
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 27.02.2013; Amer Chemical Soc
• Subjects: 3T3-L1 Cells; Agriculture; Agriculture, Multidisciplinary; Animals; benzophenone; Benzophenones - chemistry; Benzophenones - isolation & purification; Benzophenones - pharmacology; Biological and medical sciences; Chemistry; Chemistry, Applied; Down-Regulation - drug effects; fatty acids; Food industries; Food Science & Technology; Fundamental and applied biological sciences. Psychology; Glucosides - chemistry; Glucosides - isolation & purification; Glucosides - pharmacology; leaves; Life Sciences & Biomedicine; Mangifera - chemistry; Mangifera indica; Mass Spectrometry; Mice; Molecular Structure; Physical Sciences; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Leaves - chemistry; Science & Technology; Triglycerides - metabolism; triglyceride accumulation inhibition; benzophenone C-glucosides; MS fragment cleavage pathways; Mangifera indica; ACTIVATED PROTEIN-KINASE; Evaluation; Glucoside; Lipids; Plant leaf; Triglyceride; Plant part; Dicotyledones; Angiospermae; Isolation; Spermatophyta; Inhibition; Anacardiaceae

Seventy percent ethanol–water extract from the leaves of Mangifera indica L. (Anacardiaceae) was found to show an inhibitory effect on triglyceride (TG) accumulation in 3T3-L1 cells. From the active fraction, six new benzophenone C-glucosides, foliamangiferosides A3 (1), A4 (2), C4 (3), C5 (4), C6 (...