Isolation, Structural Elucidation, MS Profiling, and Evaluation of Triglyceride Accumulation Inhibitory Effects of Benzophenone C‑Glucosides from Leaves of Mangifera indica L

• Published in: Journal of agricultural and food chemistry Vol. 61; no. 8; pp. 1884 - 1895
• Main Authors: Zhang, Yi, Han, Lifeng, Ge, Dandan, Liu, Xuefeng, Liu, Erwei, Wu, Chunhua, Gao, Xiumei, Wang, Tao
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 27.02.2013; Amer Chemical Soc
• Subjects: 3T3-L1 Cells; Agriculture; Agriculture, Multidisciplinary; Animals; benzophenone; Benzophenones - chemistry; Benzophenones - isolation & purification; Benzophenones - pharmacology; Biological and medical sciences; Chemistry; Chemistry, Applied; Down-Regulation - drug effects; fatty acids; Food industries; Food Science & Technology; Fundamental and applied biological sciences. Psychology; Glucosides - chemistry; Glucosides - isolation & purification; Glucosides - pharmacology; leaves; Life Sciences & Biomedicine; Mangifera - chemistry; Mangifera indica; Mass Spectrometry; Mice; Molecular Structure; Physical Sciences; Plant Extracts - chemistry; Plant Extracts - isolation & purification; Plant Extracts - pharmacology; Plant Leaves - chemistry; Science & Technology; Triglycerides - metabolism; triglyceride accumulation inhibition; benzophenone C-glucosides; MS fragment cleavage pathways; Mangifera indica; ACTIVATED PROTEIN-KINASE; Evaluation; Glucoside; Lipids; Plant leaf; Triglyceride; Plant part; Dicotyledones; Angiospermae; Isolation; Spermatophyta; Inhibition; Anacardiaceae
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/jf305256w

Seventy percent ethanol–water extract from the leaves of Mangifera indica L. (Anacardiaceae) was found to show an inhibitory effect on triglyceride (TG) accumulation in 3T3-L1 cells. From the active fraction, six new benzophenone C-glucosides, foliamangiferosides A3 (1), A4 (2), C4 (3), C5 (4), C6 (5), and C7 (6) together with 11 known benzophenone C-glucosides (7–17) were obtained. In this paper, isolation, structure elucidation (1–6), and MS fragment cleavage pathways of all 17 isolates were studied. 1–6 showed inhibitory effects on TG and free fatty acid accumulation in 3T3-L1 cells at 10 μM.