Antifungal and Larvicidal Compounds from the Root Bark of Cordia alliodora

• Published in: Journal of natural products (Washington, D.C.) Vol. 63; no. 3; pp. 424 - 426
• Main Authors: Ioset, Jean-Robert, Marston, Andrew, Gupta, Mahabir P, Hostettmann, Kurt
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.03.2000; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Aedes aegypti; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; antifungal properties; bark; Biological and medical sciences; chemical constituents of plants; Chemical control; chemical structure; Chemistry, Medicinal; Cladosporium cucumerinum; Control; Cordia alliodora; derivatives; disease transmission; Fundamental and applied biological sciences. Psychology; Fungal plant pathogens; General pharmacology; Hydroquinones - chemistry; Hydroquinones - isolation & purification; Hydroquinones - pharmacology; Larva - drug effects; Life Sciences & Biomedicine; Medical sciences; Molecular Structure; Octanes - chemistry; Octanes - isolation & purification; Octanes - pharmacology; ovicides and larvicides; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Phenylpropionates - chemistry; Phenylpropionates - isolation & purification; Phenylpropionates - pharmacology; Phytopathology. Animal pests. Plant and forest protection; plant pathogenic fungi; Plant Roots - chemistry; Plant Sciences; Plants, Medicinal - chemistry; propionic acid; Protozoa. Invertebrates; roots; Science & Technology; spectral analysis; Spectrum Analysis; yellow fever; Panama Canal Zone; Central America; Caribbean Basin; America; Triether; Insecticide; Insecta; Bark; Cladosporium cucumerinum; Pesticide crop; Diphenols; Medicinal plant; Fungi; Folk medicine; Tertiary alcohol; Parasiticid; Fungi Imperfecti; Thallophyta; Root; Aliphatic compound; Pharmacognosy; Pesticides; Dienic compound; Biological activity; Fungicide; Larva; Arthropoda; Culicidae; Plant origin; Benzenic compound; Isolation; Aedes aegypti; Invertebrata; Diptera; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np990393j

Two new natural products, a phenylpropanoid derivative characterized as 1-(3‘-methoxypropanoyl)-2,4,5-trimethoxybenzene (1) and a prenylated hydroquinone, 2-(2Z)-(3-hydroxy-3,7-dimethylocta-2,6-dienyl)-1,4-benzenediol (2), have been isolated from the root bark of Cordia alliodora. Both compounds exhibited antifungal properties against the phytopathogenic mold Cladosporium cucumerinum. The phenylpropanoid derivative (1), whose structure is closely related to β-asarone, also demonstrated a marked activity against larvae of the yellow-fever-transmitting mosquito Aedes aegypti.