Laminaria Japonica Polysaccharide Improved the Productivities and Systemic Health of Ducks by Mediating the Gut Microbiota and Metabolome

• Published in: Journal of agricultural and food chemistry Vol. 71; no. 19; pp. 7382 - 7395
• Main Authors: Liu, Anxin, Kim, Eunyoung, Cui, Jiamei, Li, Jing, Lee, Yunkyoung, Zhang, Guiguo
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 17.05.2023
• Subjects: Animals; Bioactive Constituents, Metabolites, and Functions; Ducks; Gastrointestinal Microbiome; Laminaria; Metabolome; Polysaccharides - pharmacology; Laminaria japonica polysaccharide; health parameters; ducks; intestinal microbiome; metabolome
• ISSN: 0021-8561; 1520-5118
• DOI: 10.1021/acs.jafc.2c08731

This study investigated the beneficial effects of a Laminaria japonica polysaccharide (LJPS) on the systemic health of ducks by modulating the gut microbiome and metabolome. Our findings demonstrated that the LJPS supplementation enhanced the overall growth performance and physiological immune and antioxidant index of ducks. In addition, the LJPS-fed group significantly increased abundances of intestinal Bacteroides and Prevotellaceae with decreased α-diversity than that in the control group. Among the total of 1840 intestinal metabolites, 186 metabolites were identified to be differentially regulated by LJPS feeding (upregulated 143 metabolites and downregulated 43 metabolites), which is closely associated with some of the growth-related metabolic pathways. Lastly, the correlation analysis recapitulates that the beneficial effects of LJPS underlie the alterations in intestinal microbiota and metabolites. Taken together, LJPS supplementation improved the physiological parameters and richness of some beneficial microbes and upregulated certain metabolic pathways, which facilitated better productivities and systemic health of ducks.