Sulfate assimilation regulates antioxidant defense response of the cyanobacterium Synechococcus elongatus PCC 7942 to high concentrations of carbon dioxide

• Published in: Applied and environmental microbiology Vol. 91; no. 4; p. e0011525
• Main Authors: Mu, Yujie, Chen, Huiting, Li, Jianwei, Han, Pei, Yan, Zhen
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 23.04.2025
• Subjects: Antioxidants; Antioxidants - metabolism; Assimilation; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biotechnology; Carbon dioxide; Carbon Dioxide - metabolism; Cell culture; Comparative analysis; Cyanobacteria; Ecophysiology; Elongation; Evolution & development; Exposure; Gene Expression Regulation, Bacterial; Genomic analysis; Low concentrations; Oxidative Stress; Physiological effects; Physiology; Physiology and Metabolism; Spotlight Selection; Sulfates; Sulfates - metabolism; Synechococcus - drug effects; Synechococcus - genetics; Synechococcus - metabolism; Synechococcus elongatus; carbon dioxide; oxidative stress; cyanobacteria; sulfate assimilation; metabolic regulation
• ISSN: 0099-2240; 1098-5336; 1098-5336
• DOI: 10.1128/aem.00115-25

Cyanobacteria that grow autotrophically with CO 2 as the sole carbon source can be subject to high-CO 2 stress in a variety of biotechnological and ecological scenarios. However, physiological regulation of cyanobacteria in response to high-CO 2 stress remains elusive. Here, we employed microbial physiological, biochemical, and genetic techniques to reveal the regulatory strategies of cyanobacteria in response to high-CO 2 stress. This study, albeit physiological, provides a biotechnological enterprise for manipulating cyanobacteria as the chassis for CO 2 conversion and sheds light on the in situ ecological effects of high CO 2 on cyanobacteria.