P‑Bodies: Composition, Properties, and Functions

• Published in: Biochemistry (Easton) Vol. 57; no. 17; pp. 2424 - 2431
• Main Authors: Luo, Yang, Na, Zhenkun, Slavoff, Sarah A
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 01.05.2018
• Subjects: Cytoplasmic Granules - genetics; droplets; eukaryotic cells; Gene Expression Regulation - genetics; granules; liquids; messenger RNA; Proteins - genetics; ribonucleoproteins; Ribonucleoproteins - genetics; RNA Processing, Post-Transcriptional - genetics; RNA Stability - genetics; RNA, Messenger - genetics; separation; translation (genetics)

Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily composed of translationally repressed mRNAs and proteins related to mRNA decay, suggesting roles in post-transcriptional regulation. P-bodies are conserved in eukaryotic cells and exhibit properties of liquid dro...