P‑Bodies: Composition, Properties, and Functions

Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily composed of translationally repressed mRNAs and proteins related to mRNA decay, suggesting roles in post-transcriptional regulation. P-bodies are conserved in eukaryotic cells and exhibit properties of liquid dro...

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Published inBiochemistry (Easton) Vol. 57; no. 17; pp. 2424 - 2431
Main Authors Luo, Yang, Na, Zhenkun, Slavoff, Sarah A
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 01.05.2018
Subjects
Cytoplasmic Granules - genetics
droplets
eukaryotic cells
Gene Expression Regulation - genetics
granules
liquids
messenger RNA
Proteins - genetics
ribonucleoproteins
Ribonucleoproteins - genetics
RNA Processing, Post-Transcriptional - genetics
RNA Stability - genetics
RNA, Messenger - genetics
separation
translation (genetics)
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Summary:Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily composed of translationally repressed mRNAs and proteins related to mRNA decay, suggesting roles in post-transcriptional regulation. P-bodies are conserved in eukaryotic cells and exhibit properties of liquid droplets. However, the function of P-bodies in translational repression and/or mRNA decay remains contentious. Here we review recent advances in our understanding of the molecular composition of P-bodies, the interactions and processes that regulate P-body liquid–liquid phase separation (LLPS), and the cellular localization of mRNA decay machinery, in the context of how these discoveries refine models of P-body function.
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ISSN:0006-2960
1520-4995
1520-4995
DOI:10.1021/acs.biochem.7b01162