P‑Bodies: Composition, Properties, and Functions
Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily composed of translationally repressed mRNAs and proteins related to mRNA decay, suggesting roles in post-transcriptional regulation. P-bodies are conserved in eukaryotic cells and exhibit properties of liquid dro...
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| Published in | Biochemistry (Easton) Vol. 57; no. 17; pp. 2424 - 2431 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Chemical Society
01.05.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily composed of translationally repressed mRNAs and proteins related to mRNA decay, suggesting roles in post-transcriptional regulation. P-bodies are conserved in eukaryotic cells and exhibit properties of liquid droplets. However, the function of P-bodies in translational repression and/or mRNA decay remains contentious. Here we review recent advances in our understanding of the molecular composition of P-bodies, the interactions and processes that regulate P-body liquid–liquid phase separation (LLPS), and the cellular localization of mRNA decay machinery, in the context of how these discoveries refine models of P-body function. |
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| AbstractList | Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily composed of translationally repressed mRNAs and proteins related to mRNA decay, suggesting roles in post-transcriptional regulation. P-bodies are conserved in eukaryotic cells and exhibit properties of liquid droplets. However, the function of P-bodies in translational repression and/or mRNA decay remains contentious. Here we review recent advances in our understanding of the molecular composition of P-bodies, the interactions and processes that regulate P-body liquid–liquid phase separation (LLPS), and the cellular localization of mRNA decay machinery, in the context of how these discoveries refine models of P-body function. Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily composed of translationally repressed mRNAs and proteins related to mRNA decay, suggesting roles in post-transcriptional regulation. P-bodies are conserved in eukaryotic cells and exhibit properties of liquid droplets. However, the function of P-bodies in translational repression and/or mRNA decay remains contentious. Here we review recent advances in our understanding of the molecular composition of P-bodies, the interactions and processes that regulate P-body liquid-liquid phase separation (LLPS), and the cellular localization of mRNA decay machinery, in the context of how these discoveries refine models of P-body function.Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily composed of translationally repressed mRNAs and proteins related to mRNA decay, suggesting roles in post-transcriptional regulation. P-bodies are conserved in eukaryotic cells and exhibit properties of liquid droplets. However, the function of P-bodies in translational repression and/or mRNA decay remains contentious. Here we review recent advances in our understanding of the molecular composition of P-bodies, the interactions and processes that regulate P-body liquid-liquid phase separation (LLPS), and the cellular localization of mRNA decay machinery, in the context of how these discoveries refine models of P-body function. Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily composed of translationally repressed mRNAs and proteins related to mRNA decay, suggesting roles in post-transcriptional regulation. P-bodies are conserved in eukaryotic cells and exhibit properties of liquid droplets. However, the function of P-bodies in translational repression and/or mRNA decay remains contentious. Here we review recent advances in our understanding of the molecular composition of P-bodies, the interactions and processes that regulate P-body liquid–liquid phase separation (LLPS), and the cellular localization of mRNA decay machinery, in the context of how these discoveries refine models of P-body function. |
| Author | Na, Zhenkun Slavoff, Sarah A Luo, Yang |
| AuthorAffiliation | Department of Chemistry Yale University Department of Molecular Biophysics and Biochemistry Chemical Biology Institute |
| AuthorAffiliation_xml | – name: Department of Chemistry – name: Yale University – name: Chemical Biology Institute – name: Department of Molecular Biophysics and Biochemistry |
| Author_xml | – sequence: 1 givenname: Yang surname: Luo fullname: Luo, Yang organization: Yale University – sequence: 2 givenname: Zhenkun surname: Na fullname: Na, Zhenkun organization: Yale University – sequence: 3 givenname: Sarah A orcidid: 0000-0002-4443-2070 surname: Slavoff fullname: Slavoff, Sarah A email: sarah.slavoff@yale.edu organization: Yale University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29381060$$D View this record in MEDLINE/PubMed |
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| Snippet | Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily composed of translationally repressed mRNAs and proteins related to... Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily composed of translationally repressed mRNAs and proteins related to... |
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| SubjectTerms | Cytoplasmic Granules - genetics droplets eukaryotic cells Gene Expression Regulation - genetics granules liquids messenger RNA Proteins - genetics ribonucleoproteins Ribonucleoproteins - genetics RNA Processing, Post-Transcriptional - genetics RNA Stability - genetics RNA, Messenger - genetics separation translation (genetics) |
| Title | P‑Bodies: Composition, Properties, and Functions |
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