Graphene-Based Platform for Infrared Near-Field Nanospectroscopy of Water and Biological Materials in an Aqueous Environment

Scattering scanning near-field optical microscopy (s-SNOM) has emerged as a powerful nanoscale spectroscopic tool capable of characterizing individual biomacromolecules and molecular materials. However, applications of scattering-based near-field techniques in the infrared (IR) to native biosystems...

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Published inACS nano Vol. 9; no. 8; pp. 7968 - 7975
Main Authors Khatib, Omar, Wood, Joshua D, McLeod, Alexander S, Goldflam, Michael D, Wagner, Martin, Damhorst, Gregory L, Koepke, Justin C, Doidge, Gregory P, Rangarajan, Aniruddh, Bashir, Rashid, Pop, Eric, Lyding, Joseph W, Thiemens, Mark H, Keilmann, Fritz, Basov, D. N
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 25.08.2015
Subjects
Aqueous environments
Biological materials
Graphene
Graphite - chemistry
Imaging
Infrared
Liquids
Nanostructure
Nanotechnology - instrumentation
Nanotechnology - methods
Spectroscopy, Fourier Transform Infrared - instrumentation
Spectroscopy, Fourier Transform Infrared - methods
Tobacco Mosaic Virus - ultrastructure
Water - chemistry
infrared nanospectroscopy
near-field
biomaterials
nanoimaging
s-SNOM
water
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Summary:Scattering scanning near-field optical microscopy (s-SNOM) has emerged as a powerful nanoscale spectroscopic tool capable of characterizing individual biomacromolecules and molecular materials. However, applications of scattering-based near-field techniques in the infrared (IR) to native biosystems still await a solution of how to implement the required aqueous environment. In this work, we demonstrate an IR-compatible liquid cell architecture that enables near-field imaging and nanospectroscopy by taking advantage of the unique properties of graphene. Large-area graphene acts as an impermeable monolayer barrier that allows for nano-IR inspection of underlying molecular materials in liquid. Here, we use s-SNOM to investigate the tobacco mosaic virus (TMV) in water underneath graphene. We resolve individual virus particles and register the amide I and II bands of TMV at ca. 1520 and 1660 cm–1, respectively, using nanoscale Fourier transform infrared spectroscopy (nano-FTIR). We verify the presence of water in the graphene liquid cell by identifying a spectral feature associated with water absorption at 1610 cm–1.
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ISSN:1936-0851
1936-086X
DOI:10.1021/acsnano.5b01184