Weight Gain Associated With Increased Food Intake and Low Habitual Activity Levels in Male Adolescent Schizophrenic Inpatients Treated With Olanzapine

• Published in: The American journal of psychiatry Vol. 159; no. 6; pp. 1055 - 1057
• Main Authors: Gothelf, Doron, Falk, Bareket, Singer, Pierre, Kairi, Michal, Phillip, Moshe, Zigel, Levana, Poraz, Irit, Frishman, Siegal, Constantini, Naama, Zalsman, Gil, Weizman, Abraham, Apter, Alan
• Format: Journal Article
• Language: English
• Published: Washington, DC American Psychiatric Publishing 01.06.2002; American Psychiatric Association
• Subjects: Adolescent; Adolescent boys; Age Factors; Antipsychotic Agents - adverse effects; Antipsychotic Agents - therapeutic use; Benzodiazepines; Biological and medical sciences; Body Mass Index; Drug therapy; Drug toxicity and drugs side effects treatment; Eating - drug effects; Energy Intake - drug effects; Energy Metabolism - drug effects; Energy Metabolism - physiology; Exercise; Food; Haloperidol; Haloperidol - adverse effects; Haloperidol - therapeutic use; Hospitalization; Hospitals; Humans; Male; Males; Medical sciences; Miscellaneous (drug allergy, mutagens, teratogens...); Obesity - chemically induced; Olanzapine; Pharmacology. Drug treatments; Physical Exertion - drug effects; Physical Exertion - physiology; Pilot Projects; Pirenzepine - adverse effects; Pirenzepine - analogs & derivatives; Pirenzepine - therapeutic use; Schizophrenia; Schizophrenia - drug therapy; Teenagers; Treatment; Weight control; Weight gain; Weight Gain - drug effects; Physical exercise; Olanzapine; Neuroleptic; Psychotropic; Toxicity; Schizophrenia; Male; Haloperidol; Weight gain; Psychosis; Antagonist; Human; Dopamine antagonist; Serotonin antagonist; Prediction; Butyrophenone derivatives; Chemotherapy; D2 Dopamine receptor; Treatment; Food intake; Follow up study; Adolescent; Caloric balance; Atypical; Comparative study
• ISSN: 0002-953X; 1535-7228
• DOI: 10.1176/appi.ajp.159.6.1055

OBJECTIVE: The authors studied weight gain mechanisms and energy balance in patients treated with olanzapine. METHOD: The body mass index of male schizophrenic adolescent inpatients treated with olanzapine (N=10) and of 10 matched patients treated with haloperidol (N=10) were measured at baseline and after 4 weeks of treatment. For the patients treated with olanzapine, caloric intake, resting energy expenditure, and physical activity (determined through accelerometry and heart rate monitoring) were assessed at baseline and after 4 weeks of treatment. RESULTS: Body mass index significantly increased in those treated with olanzapine but not in those given haloperidol. The increase in body mass index was due to an increase in caloric intake without change in diet composition. Olanzapine had no significant effect on resting energy expenditure. Daily energy expenditure was very low before and after treatment. CONCLUSIONS: Olanzapine-induced weight gain is associated with a general increase in caloric intake.