Synthesis of cis- and trans-Diisothiocyanato−Bis(NHC) Complexes of Nickel(II) and Applications in the Kumada−Corriu Reaction

• Published in: Organometallics Vol. 29; no. 17; pp. 3746 - 3752
• Main Authors: Jothibasu, Ramasamy, Huang, Kuo-Wei, Huynh, Han Vinh
• Format: Journal Article
• Language: English
• Published: American Chemical Society 13.09.2010
• ISSN: 0276-7333; 1520-6041
• DOI: 10.1021/om100241v

Metathetical reaction of AgSCN with a series of trans-dihalido-bis(carbene) nickel(II) complexes in CH3CN readily afforded the novel diisothiocyanato-bis(carbene) complexes [Ni(NCS)2(NHC)2] (trans-2a, NHC = 1,3-diisopropylbenzimidazolin-2-ylidene; trans -2b, NHC = 1,3-diisobutylbenzimidazolin-2-ylidene; trans -2c, NHC = 1,3-dibenzylbenzimidazolin-2-ylidene; cis-2d, NHC = 1,3-di(2-propenyl)benzimidazolin-2-ylidene; cis-2e, NHC = 1-propyl-3-methylbenzimidazolin-2-ylidene) as greenish-yellow powders in moderate to good yields. While dihalido-bis(carbene) Ni(II) complexes exclusively form trans-complexes, a trans−cis isomerization occurs upon halido−isothiocyanato exchange with complexes bearing less bulky carbene ligands, i.e., cis- 2d/e. DFT calculations indicated that this isomerization can be attributed to a reduced energy difference between trans- and cis-isomers of diisothiocyanato complexes. All complexes have been characterized by multinuclear NMR spectroscopy, ESI mass spectrometry, and X-ray diffraction analysis. A catalytic study revealed that cis-complexes generally exhibit greater activities in the Kumada−Corriu coupling reaction.