Polymer Topology Determines the Formation of Protein Corona on Core–Shell Nanoparticles

Linear and cyclic poly­(2-ethyl-2-oxazoline) (PEOXA) adsorbates provide excellent colloidal stability to superparamagnetic iron oxide nanoparticles (Fe x O y NPs) within protein-rich media. However, dense shells of linear PEOXA brushes cannot prevent weak but significant attractive interactions with...

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Published inACS nano Vol. 14; no. 10; pp. 12708 - 12718
Main Authors Schroffenegger, Martina, Leitner, Nikolaus S, Morgese, Giulia, Ramakrishna, Shivaprakash N, Willinger, Max, Benetti, Edmondo M, Reimhult, Erik
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 27.10.2020
Subjects
Adsorption
Calorimetry
Humans
Nanoparticles
Polymers
Protein Corona
cyclic polymers
protein adsorption
isothermal titration calorimetry
protein corona
polymer brushes
poly(2-oxazoline)
inorganic nanoparticles
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Summary:Linear and cyclic poly­(2-ethyl-2-oxazoline) (PEOXA) adsorbates provide excellent colloidal stability to superparamagnetic iron oxide nanoparticles (Fe x O y NPs) within protein-rich media. However, dense shells of linear PEOXA brushes cannot prevent weak but significant attractive interactions with human serum albumin. In contrast, their cyclic PEOXA counterparts quantitatively hinder protein adsorption, as demonstrated by a combination of dynamic light scattering and isothermal titration calorimetry. The cyclic PEOXA brushes generate NP shells that are denser and more compact than their linear counterparts, entirely preventing the formation of a protein corona as well as aggregation, even when the lower critical solution temperature of PEOXA in a physiological buffer is reached.
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ISSN:1936-0851
1936-086X
DOI:10.1021/acsnano.0c02358