Rational Design of Multifunctional Gold Nanoparticles via Host–Guest Interaction for Cancer-Targeted Therapy

• Published in: ACS applied materials & interfaces Vol. 7; no. 31; pp. 17171 - 17180
• Main Authors: Chen, Wei-Hai, Lei, Qi, Luo, Guo-Feng, Jia, Hui-Zhen, Hong, Sheng, Liu, Yu-Xin, Cheng, Yin-Jia, Zhang, Xian-Zheng
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 12.08.2015
• Subjects: Adamantane - chemistry; Animals; antineoplastic agents; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; apoptosis; Apoptosis - drug effects; beta-Cyclodextrins - chemistry; Cell Line, Tumor; Cercopithecus aethiops; COS Cells; Doxorubicin - chemistry; Doxorubicin - pharmacology; Drug Carriers - chemistry; Drug Carriers - metabolism; Drug Liberation; drug therapy; Endocytosis; gold; Gold - chemistry; Graphite - chemistry; Humans; in vitro studies; lysosomes; Metal Nanoparticles - chemistry; Microscopy, Confocal; nanocarriers; nanocomposites; Nanocomposites - chemistry; nanogold; neoplasm cells; neoplasms; targeted therapy; host−guest interaction; gold nanoparticles; Multifunctional; triggered release
• ISSN: 1944-8244; 1944-8252; 1944-8252
• DOI: 10.1021/acsami.5b04031

A versatile gold nanoparticle-based multifunctional nanocomposite AuNP@CD-AD-DOX/RGD was constructed flexibly via host–guest interaction for targeted cancer chemotherapy. The pH-sensitive anticancer prodrug AD-Hyd-DOX and the cancer-targeted peptide AD-PEG8-GRGDS were modified on the surface of AuNP@CD simultaneously, which endowed the resultant nanocomposite with the capability to selectively eliminate cancer cells. In vitro studies indicated that the AuNP@CD-AD-DOX/RGD nanocomposite was preferentially uptaken by cancer cells via receptor-mediated endocytosis. Subsequently, anticancer drug DOX was released rapidly upon the intracellular trigger of the acid microenvirenment of endo/lysosomes, inducing apoptosis in cancer cells. As the ideal drug nanocarrier, the multifunctional gold nanoparticles with the active targeting and controllable intracellular release ability hold the great potential in cancer therapy.