Two New Lignans with Activity against Influenza Virus from the Medicinal Plant Rhinacanthus nasutus

• Published in: Journal of natural products (Washington, D.C.) Vol. 60; no. 6; pp. 635 - 637
• Main Authors: Kernan, Michael R, Sendl, Anna, Chen, Jian Lu, Jolad, Shivinand D, Blanc, Phillipe, Murphy, James T, Stoddart, Cheryl A, Nanakorn, Weerachai, Balick, Michael J, Rozhon, Edward J
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.06.1997; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: ACANTHACEAE; Antineoplastic Agents, Phytogenic - chemistry; Antineoplastic Agents, Phytogenic - isolation & purification; Antineoplastic Agents, Phytogenic - pharmacology; ANTIVIRAL; ANTIVIRAL AGENTS; Antiviral Agents - chemistry; Antiviral Agents - isolation & purification; Antiviral Agents - pharmacology; Biological and medical sciences; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; Chemistry, Medicinal; COMPOSICION QUIMICA; COMPOSITION CHIMIQUE; DRUG PLANTS; Drug Screening Assays, Antitumor; ESPECTROMETRIA; ESTRUCTURA QUIMICA; FEUILLE; General pharmacology; HOJAS; Influenza A virus - drug effects; INFLUENZAVIRUS; INFLUENZAVIRUS A; LEAVES; Life Sciences & Biomedicine; Lignans - chemistry; Lignans - isolation & purification; Lignans - pharmacology; LIGNINAS; LIGNINE; LIGNINS; Magnetic Resonance Spectroscopy; Mass Spectrometry; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Leaves - chemistry; Plant Sciences; PLANTAS MEDICINALES; PLANTE MEDICINALE; Plants, Medicinal - chemistry; RHINACANTHIN E; RHINACANTHIN F; Science & Technology; SPECTRAL ANALYSIS; SPECTROMETRIE; SPECTROMETRY; Spectrophotometry, Ultraviolet; STEMS; STRUCTURE CHIMIQUE; TAILANDIA; TALLO; THAILAND; THAILANDE; TIGE; Viral Plaque Assay; VIRICIDAS; Thailand; Asia; ANTIVIRAL ACTIVITY; Pharmacognosy; Orthomyxoviridae; Oxygen heterocycle; Influenzavirus; In vitro; Biological activity; Medicinal plant; Virus; Acanthaceae; Influenzavirus A; Dicotyledones; Trans stereoisomer; Angiospermae; Diester; Plant origin; Bicyclic compound; Antiviral; Isolation; Lignan; Above ground plant part; Spermatophyta; Aromatic compound; Ethylenic compound; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np960613i

Two new lignans, rhinacanthin E (1) and rhinacanthin F (2), were isolated from the aerial parts of the plant Rhinacanthus nasutus. Their structures were established by detailed spectroscopic analysis. These compounds show significant antiviral activity against influenza virus type A.