Reactivity of [(PNP)Mn(CO)2] with Organophosphates
Organophosphorus nerve agents (OPAs) are a toxic class of synthetic compounds that cause adverse effects with many biological systems. Development of methods for environmental remediation and passivation has been ongoing for years. However, little progress has been made in therapeutic development fo...
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Published in | ACS Organic & Inorganic Au Vol. 3; no. 4; pp. 199 - 208 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Chemical Society
02.08.2023
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Subjects | |
Online Access | Get full text |
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Summary: | Organophosphorus nerve agents (OPAs) are a toxic class of synthetic compounds that cause adverse effects with many biological systems. Development of methods for environmental remediation and passivation has been ongoing for years. However, little progress has been made in therapeutic development for exposure victims. Given the postexposure behavior of OPA materials in enzymes such as acetylcholinesterase (AChE), development of electrophilic compounds as therapeutics may be more beneficial than the currently employed nucleophilic countermeasures. In this report, we present our studies with an electrophilic, 16-electron manganese complex ( iPrPNP)Mn(CO)2 (1) and the nucleophilic hydroxide derivative ( iPrPNHP)Mn(CO)2(OH) (2). The reactivity of 1 with phosphorus acids and the reactivity of 2 with the P–F bond of diisopropylfluorophosphate (DIPF) were studied. The role of water in both nucleophilic and electrophilic reactivity was investigated with the use of 17O-labeled water. Promising results arising from reactions of both 1 and 2 with organophosphorus substrates are reported. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 20150743PRD3; 2020LANLE372; 20220540ECR; 89233218CNA000001 LA-UR-22-31194 USDOE Laboratory Directed Research and Development (LDRD) Program USDOE Office of Science (SC), Basic Energy Sciences (BES) |
ISSN: | 2694-247X 2694-247X |
DOI: | 10.1021/acsorginorgau.3c00003 |