Luminescence Lifetime-Based Sensing Platform Based on Cyclometalated Iridium(III) Complexes for the Detection of Perfluorooctanoic Acid in Aqueous Samples

• Published in: Analytical chemistry (Washington) Vol. 96; no. 4; pp. 1565 - 1575
• Main Authors: Zhang, Kun, Carrod, Andrew J., Del Giorgio, Elena, Hughes, Joseph, Rurack, Knut, Bennet, Francesca, Hodoroaba, Vasile-Dan, Harrad, Stuart, Pikramenou, Zoe
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 30.01.2024
• Subjects: Aqueous solutions; Chemical spills; Contamination; Cost analysis; Drinking water; Fabrication; Industrial effluents; Industrial pollution; Industrial wastewater; Iridium; Iridium compounds; Lipophilic; Luminescence; Perfluoroalkyl & polyfluoroalkyl substances; Perfluorooctanoic acid; Stability analysis; Toxicity; Water pollution
• ISSN: 0003-2700; 1520-6882
• DOI: 10.1021/acs.analchem.3c04289

Luminescence lifetimes are an attractive analytical method for detection due to its high sensitivity and stability. Iridium probes exhibit luminescence with long excited-state lifetimes, which are sensitive to the local environment. Perfluorooctanoic acid (PFOA) is listed as a chemical of high concern regarding its toxicity and is classified as a “forever chemical”. In addition to strict limits on the presence of PFOA in drinking water, environmental contamination from industrial effluent or chemical spills requires rapid, simple, accurate, and cost-effective analysis in order to aid containment. Herein, we report the fabrication and function of a novel and facile luminescence sensor for PFOA based on iridium modified on gold surfaces. These surfaces were modified with lipophilic iridium complexes bearing alkyl chains, namely, IrC6 and IrC12, and Zonyl-FSA surfactant. Upon addition of PFOA, the modified surfaces IrC 6 -FSA@Au and IrC 12 -FSA @Au show the largest change in the red luminescence signal with changes in the luminescence lifetime that allow monitoring of PFOA concentrations in aqueous solutions. The platform was tested for the measurement of PFOA in aqueous samples spiked with known concentrations of PFOA and demonstrated the capacity to determine PFOA at concentrations >100 μg/L (240 nM).