Anserinones A and B:  New Antifungal and Antibacterial Benzoquinones from the Coprophilous Fungus Podospora anserina

• Published in: Journal of natural products (Washington, D.C.) Vol. 60; no. 6; pp. 629 - 631
• Main Authors: Wang, Hui-juan, Gloer, Katherine B, Gloer, James B, Scott, James A, Malloch, David
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 01.06.1997; Amer Chemical Soc; American Society of Pharmacognosy
• Subjects: Anti-Bacterial Agents; Anti-Infective Agents - isolation & purification; Anti-Infective Agents - pharmacology; ANTIBACTERIAL PROPERTIES; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; ANTIFUNGAL PROPERTIES; ANTIMICROBIAL PROPERTIES; Bacteria - drug effects; Benzoquinones - isolation & purification; Benzoquinones - pharmacology; Biological and medical sciences; CALIFORNIA; CALIFORNIE; CELL CULTURE; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; CHEMISTRY; Chemistry, Medicinal; CHIMIE; COMPOSICION QUIMICA; COMPOSITION CHIMIQUE; CULTIVO DE CELULAS; CULTURE DE CELLULE; CYTOTOXIC COMPOUNDS; DERIVATIVES; ENZYME INHIBITORS; ESPECTROMETRIA; ESTRUCTURA QUIMICA; FAECES; FECES; Fungi - drug effects; General pharmacology; HECES; INHIBIDORES DE ENZIMAS; INHIBITEUR D'ENZYME; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Medical sciences; Microbial Sensitivity Tests; Pharmacognosy. Homeopathy. Health food; Pharmacology & Pharmacy; Pharmacology. Drug treatments; Plant Sciences; PROPIEDADES ANTIMICOSICAS; PROPIEDADES ANTIMICROBIANAS; PROPRIETE ANTIFONGIQUE; PROPRIETE ANTIMICROBIENNE; QUIMICA; QUINONAS; QUINONE; QUINONES; Science & Technology; SORDARIALES; SPECTRAL ANALYSIS; SPECTROMETRIE; SPECTROMETRY; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; STEREOCHEMISTRY; STRUCTURE CHIMIQUE; SUBSTANCE TOXIQUE; SUSTANCIAS TOXICAS; TOXIC SUBSTANCES; Xylariales - drug effects; Antineoplastic agent; Podospora anserina; Pharmacognosy; Quinone; Benzoquinone derivatives; Alcohol; Cytotoxicity; Ketone; Medicinal plant; Fungi; Antifungal agent; Absolute configuration; Plant origin; Isolation; Ascomycetes; Antibacterial agent; Thallophyta; Structural analysis
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np970071k

Two new benzoquinones with antifungal, antibacterial, and cytotoxic activities have been isolated from liquid cultures of the coprophilous fungus Podospora anserina. The structures of anserinones A (1) and B (2) were assigned on the basis of MS and NMR results, and the absolute stereochemistry of 2 was deduced by analysis of 1H-NMR data for its (R)- and (S)-2-phenylbutyryl ester derivatives.