Kinetic Resolution of Axially Chiral 5- or 8‑Substituted Quinolines via Asymmetric Transfer Hydrogenation

• Published in: Journal of the American Chemical Society Vol. 138; no. 33; pp. 10413 - 10416
• Main Authors: Wang, Jie, Chen, Mu-Wang, Ji, Yue, Hu, Shu-Bo, Zhou, Yong-Gui
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 24.08.2016; Amer Chemical Soc
• Subjects: Chemistry; Chemistry, Multidisciplinary; hydrogenation; Physical Sciences; quinolines; Science & Technology; BINOL; ATROPISOMERS; CATALYSIS; ENANTIOSELECTIVE SYNTHESIS; LIGANDS; BIARYL COMPOUNDS; BRONSTED ACIDS; CONSTRUCTION; C-H ACTIVATION; PHOSPHORIC-ACIDS

An efficient kinetic resolution of axially chiral 5- or 8-substituted quinoline derivatives was developed through asymmetric transfer hydrogenation of heteroaromatic moiety, simultaneously obtaining two kinds of axially chiral skeletons with up to 209 of selectivity factor. This represents the first...