Kinetic Resolution of Axially Chiral 5- or 8‑Substituted Quinolines via Asymmetric Transfer Hydrogenation

An efficient kinetic resolution of axially chiral 5- or 8-substituted quinoline derivatives was developed through asymmetric transfer hydrogenation of heteroaromatic moiety, simultaneously obtaining two kinds of axially chiral skeletons with up to 209 of selectivity factor. This represents the first...

Full description

Saved in:
Bibliographic Details
Published inJournal of the American Chemical Society Vol. 138; no. 33; pp. 10413 - 10416
Main Authors Wang, Jie, Chen, Mu-Wang, Ji, Yue, Hu, Shu-Bo, Zhou, Yong-Gui
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 24.08.2016
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Multidisciplinary
hydrogenation
Physical Sciences
quinolines
Science & Technology
BINOL
ATROPISOMERS
CATALYSIS
ENANTIOSELECTIVE SYNTHESIS
LIGANDS
BIARYL COMPOUNDS
BRONSTED ACIDS
CONSTRUCTION
C-H ACTIVATION
PHOSPHORIC-ACIDS
Online AccessGet full text

Cover

More Information
Summary:An efficient kinetic resolution of axially chiral 5- or 8-substituted quinoline derivatives was developed through asymmetric transfer hydrogenation of heteroaromatic moiety, simultaneously obtaining two kinds of axially chiral skeletons with up to 209 of selectivity factor. This represents the first successful application of asymmetric transfer hydrogenation of heteroaromatics in kinetic resolution of axially chiral biaryls.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0002-7863
1520-5126
1520-5126
DOI:10.1021/jacs.6b06009