Tracking of Mitochondrial Endogenous Ribonucleic Acid in the Cancer Cells and Macrophages Using a Novel Small-Molecular Fluorescent Probe

The expression of the genetic information on protein is achieved by mitochondrial RNA (mtRNA). However, mtRNA tracking in biological systems is bound due to the lack of an effective method. To solve this pressing problem, we construct a low molecular weight probe MR-IDE to track endogenous mtRNA in...

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Bibliographic Details
Published inAnalytical chemistry (Washington) Vol. 91; no. 3; pp. 1715 - 1718
Main Authors Liu, Yong, Niu, Jie, Wang, Weishan, Lin, Weiying
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 05.02.2019
Subjects
Analytical chemistry
Cancer
Chemistry
Fluorescent indicators
Gene expression
Low molecular weights
Macrophages
Mitochondria
Molecular weight
Proteins
Ribonucleic acid
RNA
System effectiveness
Tracking
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Summary:The expression of the genetic information on protein is achieved by mitochondrial RNA (mtRNA). However, mtRNA tracking in biological systems is bound due to the lack of an effective method. To solve this pressing problem, we construct a low molecular weight probe MR-IDE to track endogenous mtRNA in the cancer cells and macrophages for the first time.
Bibliography:ObjectType-Article-1
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ISSN:0003-2700
1520-6882
DOI:10.1021/acs.analchem.8b05305