Catalytic Hydrodifluoroalkylation of Unactivated Olefins

Herein, we report a modular catalytic technique that streamlines the preparation of gem-difluoroalkanes from unactivated sp 3 precursors. The method is characterized by its simplicity, generality, and site selectivity, including the functionalization of advanced intermediates and olefin feedstocks....

Full description

Saved in:
Bibliographic Details
Published inOrganic letters Vol. 24; no. 28; pp. 5109 - 5114
Main Authors Yue, Wen-Jun, Day, Craig S., Brenes Rucinski, Adrian J., Martin, Ruben
Format Journal Article
LanguageEnglish
Published American Chemical Society 22.07.2022
Subjects
Letter
Online AccessGet full text

Cover

More Information
Summary:Herein, we report a modular catalytic technique that streamlines the preparation of gem-difluoroalkanes from unactivated sp 3 precursors. The method is characterized by its simplicity, generality, and site selectivity, including the functionalization of advanced intermediates and olefin feedstocks. Our approach is enabled by a cooperative interplay of halogen- and hydrogen-atom transfer, thus offering a new entry point to difluorinated alkyl bioisosteres of interest in drug discovery.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.2c01941