In vivo efficacy of a new fluoroquinolone, sparfloxacin, against penicillin-susceptible and -resistant and multiresistant strains of Streptococcus pneumoniae in a mouse model of pneumonia

• Published in: Antimicrobial Agents and Chemotherapy Vol. 36; no. 12; pp. 2698 - 2703
• Main Authors: Azoulay-Dupuis, E, Vallee, E, Veber, B, Bedos, J P, Bauchet, J, Pocidalo, J J
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.12.1992
• Subjects: Animals; Anti-Infective Agents; Anti-Infective Agents - pharmacokinetics; Anti-Infective Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Biological and medical sciences; Ciprofloxacin - pharmacokinetics; Ciprofloxacin - therapeutic use; Disease Models, Animal; Female; Fluoroquinolones; Leukopenia - drug therapy; Lung - microbiology; Medical sciences; Mice; Mice, Inbred C57BL; Penicillin Resistance; Pharmacology. Drug treatments; Pneumonia, Pneumococcal; Pneumonia, Pneumococcal - blood; Pneumonia, Pneumococcal - drug therapy; Pneumonia, Pneumococcal - microbiology; Quinolones; Quinolones - pharmacokinetics; Quinolones - therapeutic use; Research Article; Species Specificity; Streptococcus pneumoniae; Streptococcus pneumoniae - drug effects; Streptococcus pneumoniae - genetics; Quinolone derivative; Pneumonia; Respiratory disease; Rodentia; Oral administration; Macrolide; Streptococcus pneumoniae; Resistance; Streptococcaceae; Vertebrata; Chemotherapy; Experimental disease; Mammalia; Treatment; Mouse; Animal; Multiple resistance; Penicillin; Bacteria; Micrococcales; Subcutaneous administration; Antibacterial agent; Pharmacokinetics
• ISSN: 0066-4804; 1098-6596
• DOI: 10.1128/AAC.36.12.2698

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