A Readily Available Trifluoromethylation Reagent and Its Difunctionalization of Alkenes

Trifluoromethyl substitution is notably popular in pharmaceuticals and agrochemicals; however, trifluoromethylated compounds normally rely on the use of cost-prohibitive or gaseous trifluoromethylating reagents, which diminishes the general applicability of these methods. Herein an efficient trifluo...

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Bibliographic Details
Published inOrganic letters Vol. 23; no. 15; pp. 6079 - 6083
Main Authors Zhang, Min, Lin, Jin-Hong, Xiao, Ji-Chang
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 06.08.2021
Amer Chemical Soc
Subjects
agrochemicals
alkenes
Chemistry
Chemistry, Organic
drugs
feedstocks
photocatalysis
Physical Sciences
Science & Technology
STYRENES
OXY
PHOTOREDOX
AMINO
ARENES
REACTIVITY
ACID ANHYDRIDES
C-H TRIFLUOROMETHYLATION
PERFLUOROALKYLATION
EFFICIENT
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Summary:Trifluoromethyl substitution is notably popular in pharmaceuticals and agrochemicals; however, trifluoromethylated compounds normally rely on the use of cost-prohibitive or gaseous trifluoromethylating reagents, which diminishes the general applicability of these methods. Herein an efficient trifluoromethylation reagent trifluoromethylsulfonyl–pyridinium salt (TFSP) was reported, which can be readily prepared from cheap and easily available bulk industrial feedstocks. TFSP can generate a trifluoromethyl radical under photocatalysis and realize the effective azido- or cyano-trifluoromethylation reactions of alkenes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1523-7060
1523-7052
1523-7052
DOI:10.1021/acs.orglett.1c02146