A Comparison of Cerebral SPECT Abnormalities in HIV-Positive Homosexual Men With and Without Cognitive Impairment

• Published in: Archives of neurology (Chicago) Vol. 52; no. 12; pp. 1170 - 1173
• Main Authors: Sacktor, Ned, Van Heertum, Ronald L, Dooneief, George, Gorman, Jack, Khandji, Alexander, Marder, Karen, Nour, Ramy, Todak, George, Stern, Yaakov, Mayeux, Richard
• Format: Journal Article
• Language: English
• Published: Chicago, IL American Medical Association 01.12.1995
• Subjects: Adult; AIDS/HIV; Biological and medical sciences; Brain - diagnostic imaging; Brain - pathology; Cognition Disorders - diagnosis; Cognition Disorders - diagnostic imaging; Cognition Disorders - etiology; HIV Infections - complications; HIV Infections - diagnostic imaging; HIV Infections - psychology; Homosexuality, Male; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Linear Models; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; Neuropsychological Tests; Organotechnetium Compounds; Oximes; Psychomotor Performance; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon; Radionuclide study; Human; Immunopathology; Homosexuality; Seropositivity; Cognitive disorder; Retroviridae; Exploration; Male; AIDS; Technetium; Immune deficiency; Photon; Infection; Virus; Viral disease; Lentivirinae; Diagnosis; Human immunodeficiency virus; Comparative study; Emission tomography
• ISSN: 0003-9942; 1538-3687
• DOI: 10.1001/archneur.1995.00540360048015

OBJECTIVE: To determine whether technetium Tc 99m exametazime (HMPAO) single-photon emission computed tomography (SPECT) can distinguish between human immunodeficiency virus (HIV)-positive homosexual men with normal neuropsychologic test results and HIV-positive homosexual men with abnormal neuropsychologic test results. DESIGN: Neurologic, neuropsychologic, magnetic resonance imaging, and Tc 99m HMPAO SPECT examinations were performed on 10 HIV-positive homosexual men without cognitive impairment and five HIV-positive homosexual men with cognitive impairment. PATIENTS: Human immunodeficiency virus—positive homosexual men from New York City were recruited for the study. MAIN OUTCOME MEASURES: Findings on SPECT scans were evaluated qualitatively for focal defects, heterogeneity of the cortical margin, white matter hypoperfusion, and decreased global cortical uptake. All SPECT focal defects were coregistered with magnetic resonance images; SPECT heterogeneity and global cortical uptake were also measured quantitatively. RESULTS: Coregistration with magnetic resonance imaging revealed that 63% of the focal SPECT defects corresponded to brain gyri and 37% corresponded to sulci. There was no significant difference in the frequency of qualitative or quantitative SPECT abnormalities between HIV-positive homosexual men with and without cognitive impairment. However, after examining individual neuropsychologic test factors, impaired motor speed performance was associated with decreased quantitative global cerebral uptake. CONCLUSIONS: Qualitative SPECT abnormalities are not increased in frequency in HIV-positive homosexual men with global cognitive impairment compared with those in HIV-positive homosexual men without cognitive impairment. Impaired motor speed performance may be associated with decreased quantitative global cerebral uptake.