Comparative Performance of Five Commercially Available Serologic Assays To Detect Antibodies to SARS-CoV-2 and Identify Individuals with High Neutralizing Titers

• Published in: Journal of clinical microbiology Vol. 59; no. 2
• Main Authors: Patel, Eshan U., Bloch, Evan M., Clarke, William, Hsieh, Yu-Hsiang, Boon, Denali, Eby, Yolanda, Fernandez, Reinaldo E., Baker, Owen R., Keruly, Morgan, Kirby, Charles S., Klock, Ethan, Littlefield, Kirsten, Miller, Jernelle, Schmidt, Haley A., Sullivan, Philip, Piwowar-Manning, Estelle, Shrestha, Ruchee, Redd, Andrew D., Rothman, Richard E., Sullivan, David, Shoham, Shmuel, Casadevall, Arturo, Quinn, Thomas C., Pekosz, Andrew, Tobian, Aaron A. R., Laeyendecker, Oliver
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 21.01.2021
• Subjects: Antibodies, Neutralizing - blood; Antibodies, Viral - blood; COVID-19; COVID-19 - blood; COVID-19 - diagnosis; COVID-19 Serological Testing - methods; Cross-Sectional Studies; Humans; Immune Sera - immunology; Immunoenzyme Techniques; Immunoglobulin G - blood; Neutralization Tests; SARS-CoV-2 - immunology; SARS-CoV-2 - isolation & purification; Sensitivity and Specificity; Virology; COVID-19; SARS-CoV-2; neutralizing titers; serologic assays; convalescent plasma

Accurate serological assays to detect antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are needed to characterize the epidemiology of SARS-CoV-2 infection and identify potential candidates for coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) donation. This stud...