Effect of a Neuropilin-1-Derived Virus Receptor Trap on Enterovirus A71 Infection In Vitro

We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel dom...

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Published inAntimicrobial agents and chemotherapy Vol. 65; no. 1
Main Authors Wang, Hsiang-Ching, Huang, Peng-Nien, Hung, Hui-Chen, Tseng, Sung-Nien, Chang, Chia-Chia, Tsai, Ya-Ru, Wang, Yun-Ming, Shih, Shin-Ru, Hsu, John Tsu-An
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 16.12.2020
Subjects
Antiviral Agents
neuropilin 1
enterovirus A71
decoy receptor
antiviral research
virus receptor trap
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Summary:We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel domain on the VP3 capsid protein. The principle in the design, engineering, and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy.
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Hsiang-Ching Wang, Peng-Nien Huang, and Hui-Chen Hung contributed equally to this work. Author order was determined by drawing straws.
Citation Wang H-C, Huang P-N, Hung H-C, Tseng S-N, Chang C-C, Tsai Y-R, Wang Y-M, Shih S-R, Hsu JT-A. 2021. Effect of a neuropilin-1-derived virus receptor trap on enterovirus A71 infection in vitro. Antimicrob Agents Chemother 65:e00695-20. https://doi.org/10.1128/AAC.00695-20.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.00695-20