Effect of a Neuropilin-1-Derived Virus Receptor Trap on Enterovirus A71 Infection In Vitro
We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel dom...
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Published in | Antimicrobial agents and chemotherapy Vol. 65; no. 1 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
American Society for Microbiology
16.12.2020
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Subjects | |
Online Access | Get full text |
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Summary: | We discovered that neuropilin 1 (NRP1) is a new receptor candidate to mediate enterovirus A71 (EVA71) into cells. In the engineered form as a decoy receptor, NRP1 was able to recognize and neutralize EVA71 but not enterovirus D68 or coxsackievirus B3 (CVB3). NRP1 recognizes EVA71 through a novel domain on the VP3 capsid protein. The principle in the design, engineering, and refinement of the NRP1-based decoy receptor described in this study represents a general and well-suited antiviral strategy. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Hsiang-Ching Wang, Peng-Nien Huang, and Hui-Chen Hung contributed equally to this work. Author order was determined by drawing straws. Citation Wang H-C, Huang P-N, Hung H-C, Tseng S-N, Chang C-C, Tsai Y-R, Wang Y-M, Shih S-R, Hsu JT-A. 2021. Effect of a neuropilin-1-derived virus receptor trap on enterovirus A71 infection in vitro. Antimicrob Agents Chemother 65:e00695-20. https://doi.org/10.1128/AAC.00695-20. |
ISSN: | 0066-4804 1098-6596 |
DOI: | 10.1128/AAC.00695-20 |