Escherichia coli Harboring mcr-1 in a Cluster of Liver Transplant Recipients: Detection through Active Surveillance and Whole-Genome Sequencing

, a plasmid-associated gene for colistin resistance, was first described in China in 2015, but its spread in the United States is unknown. We report detection of -carrying ST117 in a cluster of three liver transplant recipients.

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Bibliographic Details
Published inAntimicrobial agents and chemotherapy Vol. 63; no. 6
Main Authors Macesic, Nenad, Khan, Sabrina, Giddins, Marla J, Freedberg, Daniel E, Whittier, Susan, Green, Daniel A, Furuya, E Yoko, Verna, Elizabeth C, Annavajhala, Medini K, Gomez-Simmonds, Angela, Uhlemann, Anne-Catrin
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.06.2019
Subjects
Colistin
Colistin - pharmacology
Drug Resistance, Bacterial - genetics
Editor's Pick
Epidemiology and Surveillance
Escherichia coli - drug effects
Escherichia coli - genetics
Escherichia coli Proteins - genetics
Escherichia coli Proteins - metabolism
Liver Transplantation
Plasmids - genetics
Whole Genome Sequencing - methods
antimicrobial resistance
polymyxin B
whole-genome sequencing
colistin
mcr-1
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Summary:, a plasmid-associated gene for colistin resistance, was first described in China in 2015, but its spread in the United States is unknown. We report detection of -carrying ST117 in a cluster of three liver transplant recipients.
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Citation Macesic N, Khan S, Giddins MJ, Freedberg DE, Whittier S, Green DA, Furuya EY, Verna EC, Annavajhala MK, Gomez-Simmonds A, Uhlemann A-C. 2019. Escherichia coli harboring mcr-1 in a cluster of liver transplant recipients: detection through active surveillance and whole-genome sequencing. Antimicrob Agents Chemother 63:e02680-18. https://doi.org/10.1128/AAC.02680-18.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.02680-18