Limit of Detection for Rapid Antigen Testing of the SARS-CoV-2 Omicron and Delta Variants of Concern Using Live-Virus Culture

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Bibliographic Details
Published inJournal of clinical microbiology Vol. 60; no. 5; p. e0014022
Main Authors Stanley, Sydney, Hamel, Donald J, Wolf, Ian D, Riedel, Stefan, Dutta, Sanjucta, Contreras, Elisa, Callahan, Cody J, Cheng, Annie, Arnaout, Ramy, Kirby, James E, Kanki, Phyllis J
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 18.05.2022
Subjects
Clinical Microbiology
COVID-19 - diagnosis
Humans
Immunologic Tests
Letter to the Editor
Limit of Detection
SARS-CoV-2 - genetics
COVID-19
SARS-CoV-2
Delta
lateral flow assay
Omicron
analytical sensitivity
limit of detection
RT-qPCR
antigen test
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ObjectType-Correspondence-1
Elisa Contreras and Cody J. Callahan contributed equally to this article. Author order was randomly assigned by the corresponding authors. James E. Kirby and Phyllis J. Kanki are co-senior authors.
The authors declare a conflict of interest. LumiraDx provided instrumentation and diagnostic kits; Abbott provided diagnostic Ag kits; and Ginkgo Bioworks provided CareStart and Genbody antigen testing kits for the study. The BIDMC authors (J.E.K., A.C.) received support from Abbott Molecular unrelated to this study under a COVID-19 Diagnostics Evaluation Agreement. Abbott, LumiraDx, and Ginkgo Bioworks had no role in study design, manuscript preparation or decision to publish. All authors, no other conflicts of interest.
ISSN:0095-1137
1098-660X
1098-660X
DOI:10.1128/jcm.00140-22