Staphylococcus aureus Efflux Pumps and Tolerance to Ciprofloxacin and Chlorhexidine following Induction by Mupirocin

Mupirocin induced expression of genes encoding efflux pumps NorA and MepA as well as a yellow fluorescent protein (YFP) fluorescence reporter of NorA. Mupirocin exposure also produced reduced susceptibility to pump substrates ciprofloxacin and chlorhexidine, a change that was dependent on intact and...

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Published inAntimicrobial agents and chemotherapy Vol. 66; no. 2; p. e0184521
Main Authors Truong-Bolduc, Q C, Wang, Y, Reedy, J L, Vyas, J M, Hooper, D C
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 15.02.2022
Subjects
Antimicrobial Chemotherapy
Mechanisms of Resistance
chlorhexidine
NorA
MepA
Staphylococcus aureus
mupirocin
ciprofloxacin
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Summary:Mupirocin induced expression of genes encoding efflux pumps NorA and MepA as well as a yellow fluorescent protein (YFP) fluorescence reporter of NorA. Mupirocin exposure also produced reduced susceptibility to pump substrates ciprofloxacin and chlorhexidine, a change that was dependent on intact and , respectively.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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The authors declare no conflict of interest.
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.01845-21