Determination of an Aspergillus Fumigatus-Specific Immunoglobulin G Reference Range in an Adult Omani Population

• Published in: Sultan Qaboos University medical journal Vol. 18; no. 1; pp. 43 - 46
• Main Authors: Al-Rahman , Munira, Al Kindi , Mahmood, Al-Kalbani , Ibrahim, Alshekaili , Jalila, Kutty , Ibrahim
• Format: Journal Article
• Language: English
• Published: Muscat - Oman Sultan Qaboos University 01.02.2018; Sultan Qaboos University, College of Medicine and Health Sciences; Sultan Qaboos University Medical Journal, College of Medicine & Health Sciences
• Subjects: Adolescent; Adult; ADULTS; allergic bronchopulmonary aspergillosis; Allergies; ASPERGILLOSIS; Aspergillosis - immunology; Aspergillosis - metabolism; ASPERGILLUS; aspergillus fumigatus; Aspergillus fumigatus - metabolism; Aspergillus fumigatus - pathogenicity; Asthma; Blood & organ donations; Clinical & Basic Research; DIAGNOSIS; Enzyme-Linked Immunosorbent Assay - methods; Family medical history; Female; Fungal infections; GAMMA GLOBULIN; Humans; immunoglobulin g; Immunoglobulin G - analysis; Immunoglobulin G - blood; Immunoglobulins; Laboratories; Male; Medical diagnosis; Middle Aged; Municipalities; OMAN; Patients; Population; pulmonary aspergillosis; PULMONARY DISEASES; Quality control; reference range; Reference Values; Software; الأمراض الصدرية; التشخيص; الراشدون; الرشاشية; داء الرشاشيات الفطري; عمان; غاما الغلوبولين; Oman; Reference Range; Aspergillus fumigatus; Allergic Bronchopulmonary Aspergillosis; Immunoglobulin G; Oman; Pulmonary Aspergillosis
• ISSN: 2075-051X; 2075-0528
• DOI: 10.18295/squmj.2018.18.01.007

The presence of abnormally high levels of Aspergillus fumigatus-specific immunoglobulin (Ig) G antibodies can serve as a diagnostic criterion for severe conditions like allergic bronchopulmonary and chronic pulmonary aspergillosis. This study aimed to determine a reference range of A. fumigatus-specific IgG levels within a healthy adult Omani population. Methods: This study took place during November 2015 at the Sultan Qaboos University Hospital, Muscat, Oman. The sera of 125 healthy Omani blood donors were tested for A. fumigatusspecific IgG levels using an automated fluorescence enzyme immunoassay. Results: Initially, the data were not normally distributed; however, log transformation and the exclusion of four outliers resulted in an acceptable Gaussian distribution. The reference range was 2.0–68.7 mgA / L at the 2.5th and 97.5th percentiles, respectively, with 90 % confidence intervals of 2.0–3.0 mgA / L and 48.0–76.0 mgA / L, respectively. Conclusion : The A. fumigatusspecific IgG reference range within a healthy adult Omani population was comparable to those reported in other populations.