Control of Klebsiella pneumoniae Infection in Mice by Using Dissolving Microarray Patches Containing Gentamicin

Using a murine model of bacterial infection, we demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control infection. Mice treated with microarray patches had reduced bacterial burden in the nasal-associated lymphoid tissue and lungs compared with their untreate...

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Published inAntimicrobial agents and chemotherapy Vol. 63; no. 5
Main Authors Rodgers, Aoife M, McCrudden, Maelíosa T C, Courtenay, Aaron J, Kearney, Mary-Carmel, Edwards, Katherine L, Ingram, Rebecca J, Bengoechea, Jose, Donnelly, Ryan F
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.05.2019
Subjects
Animals
Anti-Bacterial Agents - therapeutic use
Disease Models, Animal
Experimental Therapeutics
Gentamicins
Gentamicins - therapeutic use
Klebsiella Infections
Klebsiella Infections - drug therapy
Klebsiella Infections - microbiology
Klebsiella pneumoniae
Klebsiella pneumoniae - drug effects
Klebsiella pneumoniae - pathogenicity
Mice
gentamicin
microarray
transdermal delivery
Klebsiella pneumoniae
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Summary:Using a murine model of bacterial infection, we demonstrate that gentamicin dissolving microarray patches, applied to murine ears, could control infection. Mice treated with microarray patches had reduced bacterial burden in the nasal-associated lymphoid tissue and lungs compared with their untreated counterparts. This proof of concept study represents the first published data on the delivery of the antibiotic gentamicin via dissolving microarray patches, resulting in the control of bacterial infection.
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Citation Rodgers AM, McCrudden MTC, Courtenay AJ, Kearney M-C, Edwards KL, Ingram RJ, Bengoechea J, Donnelly RF. 2019. Control of Klebsiella pneumoniae infection in mice by using dissolving microarray patches containing gentamicin. Antimicrob Agents Chemother 63:e02612-18. https://doi.org/10.1128/AAC.02612-18.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.02612-18