Inactivation of the Pseudomonas-Derived Cephalosporinase-3 (PDC-3) by Relebactam

is a prevalent and life-threatening Gram-negative pathogen. -derived cephlosporinase (PDC) is the major inducible cephalosporinase in In this investigation, we show that relebactam, a diazabicyclooctane β-lactamase inhibitor, potently inactivates PDC-3, with a / of 41,400 M s and a of 0.00095 s Rele...

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Published inAntimicrobial agents and chemotherapy Vol. 62; no. 5
Main Authors Barnes, Melissa D, Bethel, Christopher R, Alsop, Jim, Becka, Scott A, Rutter, Joseph D, Papp-Wallace, Krisztina M, Bonomo, Robert A
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.05.2018
Subjects
Cephalosporinase
Mechanisms of Resistance
Pseudomonas
Pseudomonas aeruginosa
AmpC
relebactam
PDC-3
imipenem
Pseudomonas aeruginosa
β-lactam
β-lactamase
diazabicyclooctane inhibitor
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Summary:is a prevalent and life-threatening Gram-negative pathogen. -derived cephlosporinase (PDC) is the major inducible cephalosporinase in In this investigation, we show that relebactam, a diazabicyclooctane β-lactamase inhibitor, potently inactivates PDC-3, with a / of 41,400 M s and a of 0.00095 s Relebactam restored susceptibility to imipenem in 62% of multidrug-resistant clinical isolates, while only 21% of isolates were susceptible to imipenem-cilastatin alone. Relebactam promises to increase the efficacy of imipenem-cilastatin against .
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Citation Barnes MD, Bethel CR, Alsop J, Becka SA, Rutter JD, Papp-Wallace KM, Bonomo RA. 2018. Inactivation of the Pseudomonas-derived cephalosporinase-3 (PDC-3) by relebactam. Antimicrob Agents Chemother 62:e02406-17. https://doi.org/10.1128/AAC.02406-17.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.02406-17