A Theranostic Two-Tone Luminescent PhotoCORM Derived from Re(I) and (2-Pyridyl)-benzothiazole: Trackable CO Delivery to Malignant Cells

A Re­(I) carbonyl complex derived from 2-(2-pyridyl)-benzothiazole (pbt), [Re­(H2O)­(CO)3(pbt)]­(CF3SO3) (1), rapidly releases CO under low-power UV illumination. CO photorelease from 1 is accompanied by a change in luminescence from orange to deep blue. These two distinct luminescence signals have...

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Published inInorganic chemistry Vol. 55; no. 16; pp. 7852 - 7858
Main Authors Carrington, Samantha J, Chakraborty, Indranil, Bernard, Jenna M. L, Mascharak, Pradip K
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 15.08.2016
Subjects
Benzothiazoles - chemistry
Breast Neoplasms - therapy
Carbon Monoxide - administration & dosage
Cell Line, Tumor
Crystallography, X-Ray
Drug Carriers - administration & dosage
Drug Carriers - chemical synthesis
Drug Carriers - chemistry
Drug Delivery Systems - methods
Female
Humans
Luminescence
Magnetic Resonance Spectroscopy
Myoglobin - metabolism
Organometallic Compounds - chemistry
Prodrugs - administration & dosage
Pyridines - chemistry
Rhenium - chemistry
Spectrometry, Fluorescence
Theranostic Nanomedicine - methods
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Summary:A Re­(I) carbonyl complex derived from 2-(2-pyridyl)-benzothiazole (pbt), [Re­(H2O)­(CO)3(pbt)]­(CF3SO3) (1), rapidly releases CO under low-power UV illumination. CO photorelease from 1 is accompanied by a change in luminescence from orange to deep blue. These two distinct luminescence signals have been successfully employed to track (a) the entry of the pro-drug 1 into cancer cells and (b) the end of the CO (drug) delivery step within the target.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0020-1669
1520-510X
DOI:10.1021/acs.inorgchem.6b00511