Efficient Multicomponent Active Template Synthesis of Catenanes

We describe a simple and high yielding active template synthesis of [2]­catenanes. In addition to mechanical bond formation using a single premacrocycle bearing an azide and alkyne moiety, our method is also suitable for the co-macrocyclization of readily available bis-alkyne and bis-azide comonomer...

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Bibliographic Details
Published inJournal of the American Chemical Society Vol. 140; no. 14; pp. 4787 - 4791
Main Authors Lewis, James E. M, Modicom, Florian, Goldup, Stephen M
Format Journal Article
LanguageEnglish
Published WASHINGTON American Chemical Society 11.04.2018
Amer Chemical Soc
Subjects
Chemistry
Chemistry, Multidisciplinary
Communication
Physical Sciences
Science & Technology
MACHINES
MACROCYCLES
CATENATION
CLICK
LIGAND
MECHANICALLY INTERLOCKED MOLECULES
PEPTIDE-SYNTHESIS
ROTAXANES
DIRECTED SYNTHESIS
SHUTTLES
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Summary:We describe a simple and high yielding active template synthesis of [2]­catenanes. In addition to mechanical bond formation using a single premacrocycle bearing an azide and alkyne moiety, our method is also suitable for the co-macrocyclization of readily available bis-alkyne and bis-azide comonomers and even short alkyne/azide components which oligomerize prior to mechanical bond formation.
Bibliography:UKRI
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.8b01602