Imidazolium Salts: A Mild Reducing and Antioxidative Reagent

• Published in: Journal of the American Chemical Society Vol. 130; no. 38; pp. 12586 - 12587
• Main Authors: Zhao, Lan, Zhang, Chunyan, Zhuo, Lang, Zhang, Yugen, Ying, Jackie Y
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 24.09.2008; Amer Chemical Soc
• Subjects: Acetylcysteine - pharmacology; Animals; Antioxidants - chemistry; Antioxidants - pharmacology; Catechin - analogs & derivatives; Catechin - pharmacology; Chemistry; Chemistry, Multidisciplinary; Dose-Response Relationship, Drug; Gold - chemistry; Hepatic Stellate Cells - drug effects; Hepatic Stellate Cells - metabolism; Imidazolines - chemistry; Imidazolines - pharmacology; Metal Nanoparticles - chemistry; Oxidative Stress; Physical Sciences; Rats; Reactive Oxygen Species - metabolism; Reducing Agents - chemistry; Reducing Agents - pharmacology; Science & Technology; GOLD NANOPARTICLES; PHASE; SINGLE; LIGANDS; STABILITY; COMPLEXES; N-HETEROCYCLIC CARBENES; DERIVATIVES; WATER; ATOM
• ISSN: 0002-7863; 1520-5126
• DOI: 10.1021/ja8037883

The concept of directly using imidazolium salts (IMSs) as mild reducing and antioxidative reagents was proposed and investigated. A simple and robust protocol for the synthesis of stable, ultrafine gold nanoparticles has been established using IMSs under mild conditions. IMSs showed remarkably lower toxicity but greater antioxidative power than N-acetyl-l-cystein and (−)-epigallocatechin gallate on HSC-T6 cells. These studies demonstrate that the simple and inexpensive IMSs represent a new type of antioxidant with potential biomedical applications